How long does the test take to process?

Results are typically available within 5-7 business days after the sample is received at our CAP-accredited and CLIA-certified laboratory.

Is Proove Pain Perception covered by insurance?

Proove's test may be covered by certain commercial insurance plans. We recommend checking with your provider or contacting our support team for a benefits verification.

Solutions

>50% of pain variability
involves genetic factors.¹

Q: How accurate is Proove Pain Perception?

The haplotype Proove Pain Perception evaluates accounts for 96% of the world's population, and its correlation with pain sensitivity to experimental pain has been shown at p<0.0004. Because genetics account for only part of pain variability, the profile also evaluates stress (via the Perceived Stress Scale), age, gender, and other factors to provide a more complete picture.

50-68%

“Genetic influences account for approximately 50% of the variance in chronic pain” and between “52% to 68% for lower back pain” — the most common chronic pain.^1,2

Beyond 0-10 scales and the “Science by Emoji” of smiley-face to frowny-face assessments, genetics, stress, and demographics can be analyzed using AI to objectively assess pain sensitivity.

Sample Report — Patients

Sample Report — Clinicians

View Clinical Evidence

CAP AccreditedCLIA CertifiedCOLA AccreditedHIPAA CompliantPublished Evidence

Personalized Pain Assessment

Replace subjective assessments with objective analysis to guide treatment & recovery from pain.

Collect the Specimen & Medications

A simple swab and form provide the biological and information specimen we need.

Analysis Instead of Guessing

Instead of a subjective assessment, a clinician can make a better-informed decision on how to treat pain and how to guide rehabilitation, physical therapy, and recovery.

Risk Mitigation

Reduce the burden of pain treatment through objective assessments to personalize treatment involving a multi-modal approach that considers stress, psychology, and pain perception.

Precision Pain Assessment Using Genetics & AI

We analyze a proprietary haplotype of genetic variations in the Catechol-O-Methyl-Transferase (COMT) gene, along with stress (Perceived Stress Scale), age, gender, and other factors to objectively assess pain perception.

96%

of the world's population is covered by the COMT haplotype Proove Pain Perception evaluates.⁶

p<0.0004

correlation between the haplotype and sensitivity to experimental pain.⁶

“Science by Emoji” Is Failing

The 0-10 Numeric Rating Scale (NRS) is the standard subjective pain assessment used today — published research shows it consistently falls short.

N=275

The NRS “may have only modest accuracy for identifying patients with clinically important pain in primary care.”³

N=528

In practice, the NRS is “less accurate than under ideal circumstances.”⁴

N=300

“The quality of pain care was unchanged before and after the pain initiative… patients who reported substantial pain…had inadequate pain management.”⁵

Proove Pain Perception® Succeeds With Better Data

Covers 96% of the World's Population

Proove Pain Perception evaluates a haplotype of the COMT gene that accounts for 96% of the world's population, and correlated with sensitivity to experimental pain (p<0.0004).⁶

Associated With Multiple Forms of Pain

The same genetic haplotype has been shown to be associated with multiple pain-evoking stimuli, not just one type of pain.⁷

A Mechanism Rooted in Molecular Biology

The variants studied influence messenger RNA local stem-loop structures, directing downstream COMT protein levels and enzymatic activity — the biological basis for differences in pain processing.⁸

Sex & Stress Modify Pain Sensitivity

Phenotypes related to sex and psychological stress were associated with pain sensitivity, which is why Proove Pain Perception also evaluates the Perceived Stress Scale, age, and gender alongside genetics.⁹

Proove Pain Perception®: Clinical Utility Data

Published outcomes from clinics that used Proove Pain Perception results to guide treatment.¹⁰

40%

of patients had treatment plans changed based on results

72%

showed improvement when medications were adjusted

69%

of physicians saw improvement from non-pharmacological changes

85%

of physicians found results consistent with patient pain levels

Frequently Asked Questions

Answers to the most common questions about Proove Pain Perception.